Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes
2013 | journal article; overview. A publication with affiliation to the University of Göttingen.
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- Authors
- Sag, Can M.; Wagner, Stefan ; Maier, Lars S.
- Abstract
- In this review article we give an overview of current knowledge with respect to redox-sensitive alterations in Na+ and Ca2+ handling in the heart. In particular, we focus on redox-activated protein kinases including cAMP-dependent protein kinase A (PKA), protein kinase C (PKC), and Ca/calmodulin-dependent protein kinase II (CaMKII), as well as on redox-regulated downstream targets such as Na+ and Ca2+ transporters and channels. We highlight the pathological and physiological relevance of reactive oxygen species and some of its sources (such as NADPH oxidases, NOXes) for excitation-contraction coupling (ECC). A short outlook with respect to the clinical relevance of redox-dependent Na+ and Ca2+ imbalance will be given. (C) 2013 Elsevier Inc. All rights reserved.
- Issue Date
- 2013
- Journal
- Free Radical Biology and Medicine
- Project
- SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz
SFB 1002 | A03: Bedeutung CaMKII-abhängiger Mechanismen für die Arrhythmogenese bei Herzinsuffizienz - Working Group
- RG L. Maier (Experimentelle Kardiologie)
- ISSN
- 0891-5849; 1873-4596
- Language
- English