Foodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates
2013 | journal article. A publication with affiliation to the University of Göttingen.
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Foodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates
Holznagel, E.; Yutzy, B.; Schulz-Schaeffer, W. J.; Kruip, C.; Hahmann, U.; Bierke, P. & Torres, J.-M. et al. (2013)
EMERGING INFECTIOUS DISEASES, 19(5) pp. 712-720. DOI: https://doi.org/10.3201/eid1905.120274
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Details
- Authors
- Holznagel, Edgar; Yutzy, Barbara; Schulz-Schaeffer, Walter J.; Kruip, Carina; Hahmann, Uwe; Bierke, Paer; Torres, Juan-Maria; Kim, Yong-Sun; Thomzig, Achim; Beekes, Michael; Hunsmann, Gerhard; Loewer, Johannes
- Abstract
- Risk for human exposure to bovine spongiform encephalopathy (BSE) inducing agent was estimated in a nonhuman primate model. To determine attack rates, incubation times, and molecular signatures, we orally exposed 18 macaques to 1 high dose of brain material from cattle with BSE. Several macaques were euthanized at regular intervals starting at 1 year postinoculation, and others were observed until clinical signs developed. Among those who received >= 5 g BSE-inducing agent, attack rates were 100% and prions could be detected in peripheral tissues from 1 year postinoculation onward. The overall median incubation time was 4.6 years (3.7-5.3). However, for 3 macaques orally exposed on multiple occasions, incubation periods were at least 7-10 years. Before clinical signs were noted, we detected a non-type 2B signature, indicating the existence of atypical prion protein during the incubation period. This finding could affect diagnosis of variant Creutzfeldt-Jakob disease in humans and might be relevant for retrospective studies of positive tonsillectomy or appendectomy specimens because time of infection is unknown.
- Issue Date
- 2013
- Status
- published
- Publisher
- Centers Disease Control
- Journal
- EMERGING INFECTIOUS DISEASES
- ISSN
- 1080-6059; 1080-6040