Intermediate filament mechanics in vitro and in the cell: from coiled coils to filaments, fibers and networks
2015-01-23 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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Intermediate filament mechanics in vitro and in the cell: from coiled coils to filaments, fibers and networks
Köster, S. ; Weitz, D. A.; Goldman, R. D.; Aebi, U. & Herrmann, H. (2015)
Current Opinion in Cell Biology, 32 pp. 82-91. DOI: https://doi.org/10.1016/j.ceb.2015.01.001
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Details
- Authors
- Köster, Sarah ; Weitz, David A.; Goldman, Robert D.; Aebi, Ueli; Herrmann, Harald
- Abstract
- Intermediate filament proteins form filaments, fibers and networks both in the cytoplasm and the nucleus of metazoan cells. Their general structural building plan accommodates highly varying amino acid sequences to yield extended dimeric alpha-helical coiled coils of highly conserved design. These 'rod' particles are the basic building blocks of intrinsically flexible, filamentous structures that are able to resist high mechanical stresses, that is, bending and stretching to a considerable degree, both in vitro and in the cell. Biophysical and computer modeling studies are beginning to unfold detailed structural and mechanical insights into these major supramolecular assemblies of cell architecture, not only in the 'test tube' but also in the cellular and tissue context.
- Issue Date
- 23-January-2015
- Journal
- Current Opinion in Cell Biology
- Organization
- Institut für Röntgenphysik
- Working Group
- RG Köster (Cellular Biophysics)
- ISSN
- 0955-0674
- eISSN
- 1879-0410
- Language
- English
- Subject(s)
- cytoskeleton; cellular biophysics