Propagation-based phase-contrast tomography for high-resolution lung imaging with laboratory sources
2016-03-08 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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- Authors
- Krenkel, Martin; Toepperwien, Mareike ; Dullin, Christian ; Alves, Frauke ; Salditt, Tim
- Abstract
- We have performed high-resolution phase-contrast tomography on whole mice with a laboratory setup. Enabled by a high-brilliance liquid- metal- jet source, we show the feasibility of propagation-based phase contrast in local tomography even in the presence of strongly absorbing surrounding tissue as it is the case in small animal imaging of the lung. We demonstrate the technique by reconstructions of the mouse lung for two different fields of view, covering the whole organ, and a zoom to the local finer structure of terminal airways and alveoli. With a resolution of a few micrometers and the wide availability of the technique, studies of larger biological samples at the cellular level become possible. (c) 2016 Author(s).
- Issue Date
- 8-March-2016
- Journal
- AIP Advances
- Organization
- Fakultät für Physik ; Institut für Röntgenphysik
- Working Group
- RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)
- ISSN
- 2158-3226
- Subject(s)
- x-ray imaging; biomedical tomography