Escherichia coli induces DNA double-strand breaks in eukaryotic cells
2006 | journal article. A publication with affiliation to the University of Göttingen.
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Escherichia coli induces DNA double-strand breaks in eukaryotic cells
Nougayrede, J.-P.; Homburg, S.; Taieb, F.; Boury, M.; Brzuszkiewicz, E. B.; Gottschalk, G. & Buchrieser, C. et al. (2006)
Science, 313(5788) pp. 848-851. DOI: https://doi.org/10.1126/science.1127059
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Details
- Authors
- Nougayrede, Jean-Philippe; Homburg, Stefan; Taieb, Frederic; Boury, Michele; Brzuszkiewicz, Elzbieta B.; Gottschalk, Gerhard; Buchrieser, Carmen; Hacker, Joerg; Dobrindt, Ulrich; Oswald, Eric
- Abstract
- Transient infection of eukaryotic cells with commensal and extraintestinal pathogenic Escherichia coli of phylogenetic group B2 blocks mitosis and induces megalocytosis. This trait is linked to a widely spread genomic island that encodes giant modular nonribosomal peptide and polyketide synthases. Contact with E. coli expressing this gene cluster causes DNA double-strand breaks and activation of the DNA damage checkpoint pathway, leading to cell cycle arrest and eventually to cell death. Discovery of hybrid peptide-polyketide genotoxins in E. coli will change our view on pathogenesis and commensalism and open new biotechnological applications.
- Issue Date
- 2006
- Status
- published
- Publisher
- Amer Assoc Advancement Science
- Journal
- Science
- ISSN
- 0036-8075