Control of Multicellular Development by the Physically Interacting Deneddylases DEN1/DenA and COP9 Signalosome
2013 | journal article. A publication with affiliation to the University of Göttingen.
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Control of Multicellular Development by the Physically Interacting Deneddylases DEN1/DenA and COP9 Signalosome
Christmann, M.; Schmaler, T.; Gordon, C.; Huang, X.; Bayram, O.; Schinke, J. & Stumpf, S. et al. (2013)
PLoS Genetics, 9(2) art. e1003275. DOI: https://doi.org/10.1371/journal.pgen.1003275
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- Authors
- Christmann, Martin; Schmaler, Tilo; Gordon, Colin; Huang, Xiaohua; Bayram, Oezguer; Schinke, Josua; Stumpf, Sina; Dubiel, Wolfgang; Braus, Gerhard H.
- Abstract
- Deneddylases remove the ubiquitin-like protein Nedd8 from modified proteins. An increased deneddylase activity has been associated with various human cancers. In contrast, we show here that a mutant strain of the model fungus Aspergillus nidulans deficient in two deneddylases is viable but can only grow as a filament and is highly impaired for multicellular development. The DEN1/DenA and the COP9 signalosome (CSN) deneddylases physically interact in A. nidulans as well as in human cells, and CSN targets DEN1/DenA for protein degradation. Fungal development responds to light and requires both deneddylases for an appropriate light reaction. In contrast to CSN, which is necessary for sexual development, DEN1/DenA is required for asexual development. The CSN-DEN1/DenA interaction that affects DEN1/DenA protein levels presumably balances cellular deneddylase activity. A deneddylase disequilibrium impairs multicellular development and suggests that control of deneddylase activity is important for multicellular development.
- Issue Date
- 2013
- Status
- published
- Publisher
- Public Library Science
- Journal
- PLoS Genetics
- ISSN
- 1553-7404
- Sponsor
- Open-Access-Publikationsfonds 2013