Diagnosis of Toxoplasmosis Using a Synthetic Glycosylphosphatidylinositol Glycan
2014 | journal article. A publication with affiliation to the University of Göttingen.
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Diagnosis of Toxoplasmosis Using a Synthetic Glycosylphosphatidylinositol Glycan
Goetze, S.; Azzouz, N.; Tsai, Y.-H.; Gross, U.; Reinhardt, A.; Anish, C. & Seeberger, P. H. et al. (2014)
Angewandte Chemie International Edition, 53(50) pp. 13701-13705. DOI: https://doi.org/10.1002/anie.201406706
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Details
- Authors
- Goetze, Sebastian; Azzouz, Nahid; Tsai, Yu-Hsuan; Gross, Uwe; Reinhardt, Anika; Anish, Chakkumkal; Seeberger, Peter H.; Silva, Daniel Varon
- Abstract
- Around 2 billion people worldwide are infected with the apicomplexan parasite Toxoplasma gondii which induces a variety of medical conditions. For example, primary infection during pregnancy can result in fetal death or mental retardation of the child. Diagnosis of acute infections in pregnant women is challenging but crucially important as the drugs used to treat T.gondii infections are potentially harmful to the unborn child. Better, faster, more reliable, and cheaper means of diagnosis by using defined antigens for accurate serological tests are highly desirable. Synthetic pathogen-specific glycosylphosphatidylinositol (GPI) glycan antigens are diagnostic markers and have been used to distinguish between toxoplasmosis disease states using human sera.
- Issue Date
- 2014
- Status
- published
- Publisher
- Wiley-v C H Verlag Gmbh
- Journal
- Angewandte Chemie International Edition
- ISSN
- 1521-3773; 1433-7851