Contribution of spinal cord biopsy to diagnosis of aquaporin-4 antibody positive neuromyelitis optica spectrum disorder
2014 | journal article. A publication with affiliation to the University of Göttingen.
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Contribution of spinal cord biopsy to diagnosis of aquaporin-4 antibody positive neuromyelitis optica spectrum disorder
Ringelstein, M.; Metz, I.; Ruprecht, K.; Koch, A.; Rappold, J.; Ingwersen, J. & Mathys, C. et al. (2014)
Multiple Sclerosis Journal, 20(7) pp. 882-888. DOI: https://doi.org/10.1177/1352458513510981
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Details
- Authors
- Ringelstein, Marius; Metz, Imke; Ruprecht, Klemens; Koch, A.; Rappold, J.; Ingwersen, Joachim; Mathys, C.; Jarius, Sven; Brueck, Wolfgang; Hartung, H-P; Paul, Friedemann; Aktas, Orhan
- Abstract
- Longitudinally extensive transverse myelitis is characteristic but not pathognomonic for neuromyelitis optica spectrum disorders (NMOSDs) and may mimic local tumors. In this retrospective study based on a cohort of 175 NMOSD patients we identified seven patients who initially presented with a longitudinally extensive spinal cord lesion and underwent spinal cord biopsy due to magnetic resonance imaging (MRI)-suspected malignancies. Remarkably, routine neuropathology was inconclusive and did not guide the diagnostic process to anti-aquaporin-4 (AQP4)-seropositive NMOSD. Serious postoperative complications occurred in 5/7 patients and persisted during follow-up in 2/7 patients (29%). Considering these sequelae, AQP4-antibody testing should be mandatory in patients with inconclusive longitudinally extensive spinal cord lesions prior to biopsy.
- Issue Date
- 2014
- Status
- published
- Publisher
- Sage Publications Ltd
- Journal
- Multiple Sclerosis Journal
- ISSN
- 1477-0970; 1352-4585
