D- and L-lactate in rabbit and human bacterial meningitis
2001 | conference paper. A publication with affiliation to the University of Göttingen.
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D- and L-lactate in rabbit and human bacterial meningitis
Wellmer, A.; Prange, J.; Gerber, J.; Zysk, G.; Lange, P.; Michel, U. & Eiffert, H. et al. (2001)
Scandinavian Journal of Infectious Diseases, 33(12) pp. 909-913. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, TORONTO, CANADA.
Oslo: Taylor & Francis As.
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Details
- Authors
- Wellmer, A.; Prange, J.; Gerber, Joachim; Zysk, G.; Lange, P.; Michel, Uwe; Eiffert, Helmut; Nau, R.
- Abstract
- Increased total CSF lactate is an important indicator differentiating bacterial from aseptic meningitis. Bacteria can produce D- and L-lactate; mammalian cells produce only L-lactate. We measured D- and L-lactate production of Streptococcus pneumoniae, Staphylococcus aureus, Neisseria meningitidis and Escherichia coli in vitro, of S. pneumoniae and E. coli in rabbit experimental meningitis and of various common pathogens in CSF from patients with bacterial meningitis. Despite marked in vitro production of D-lactate by S. aureus (maximum: 4.59 mmol/l; i.e. 34.9% of total lactate), N. meningitidis (4.62 mmol/l; i.e. 98.1%) and E. coli (3.14 mmol/l; i.e. 97.2%), minimal amounts were measured in human S. aureus (0.38 mmol/l; i.e. 1.3% of total lactate) or N. meningitidis (0.28 mmol/l; i.e. 3.9%) and experimental E. coli meningitis (0.75 mmol/l; i.e. 4.4%). In only 9 of 54 human CSF samples did D-lactate exceed 0.15 mmol/l. S. pneumoniae did not produce significant amounts of D-lactate in vitro (maximum; 0.55 mmol/l; i.e. 2.7% of total lactate), in experimental meningitis (0.18 mmol/l; i.e. 3%) or in human cases of meningitis (0.28 mmol/l; i.e. 1.9%). In conclusion, increased total CSF lactate in meningitis consists mainly of L-lactate and originates predominantly from host cells. CSF D-lactate is of limited diagnostic value.
- Issue Date
- 2001
- Status
- published
- Publisher
- Taylor & Francis As
- Journal
- Scandinavian Journal of Infectious Diseases
- Conference
- 40th Interscience Conference on Antimicrobial Agents and Chemotherapy
- Conference Place
- TORONTO, CANADA
- ISSN
- 0036-5548