Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma
2014 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma
Koch, R.; Demant, M.; Aung, T.; Diering, N.; Cicholas, A.; Chapuy, B. & Wenzel, D. et al. (2014)
Blood, 123(14) pp. 2189-2198. DOI: https://doi.org/10.1182/blood-2013-08-523886
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Details
- Authors
- Koch, Raphael; Demant, Martin; Aung, Thiha; Diering, Nina; Cicholas, Anna; Chapuy, Björn ; Wenzel, Dirk; Lahmann, Marlen; Guentsch, Annemarie; Kiecke, Christina; Becker, Sabrina; Hupfeld, Timo; Venkataramani, Vivek; Ziepert, Marita; Opitz, Lennart; Klapper, Wolfram; Truemper, Lorenz H.; Wulf, Gerald G.
- Abstract
- Tumors are composed of phenotypically heterogeneous cell populations. The non-genomic mechanisms underlying transitions and interactions between cell populations are largely unknown. Here, we show that diffuse large B-cell lymphomas possess a self-organized infrastructure comprising side population (SP) and non-SP cells, where transitions between clonogenic states are modulated by exosome-mediated Wnt signaling. DNA methylation modulated SP-non-SP transitions and was correlated with the reciprocal expressions of Wnt signaling pathway agonist Wnt3a in SP cells and the antagonist secreted frizzled-related protein 4 in non-SP cells. Lymphoma SP cells exhibited autonomous clonogenicity and exported Wnt3a via exosomes to neighboring cells, thus modulating population equilibrium in the tumor.
- Issue Date
- 2014
- Journal
- Blood
- ISSN
- 1528-0020; 0006-4971
