A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling
2006 | journal article. A publication with affiliation to the University of Göttingen.
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A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling
Hummel, M.; Bentink, S.; Berger, H.; Klapper, W.; Wessendorf, S.; Barth, T. F. E. & Bernd, H. W. et al. (2006)
New England Journal of Medicine, 354(23) pp. 2419-2430. DOI: https://doi.org/10.1056/NEJMoa055351
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- Authors
- Hummel, Michael; Bentink, Stefan; Berger, H.; Klapper, Wolfram; Wessendorf, S.; Barth, Thomas F. E.; Bernd, H. W.; Cogliatti, S. B.; Dierlamm, J.; Feller, A. C.; Hansmann, Martin Leo; Haralambieva, E.; Harder, Lana; Hasenclever, Dirk; Kuhn, M.; Lenze, Dido; Lichter, Peter; Martin-Subero, Jose I.; Moller, P.; Muller-Hermelink, H. K.; Ott, German; Parwaresch, R. M.; Pott, C.; Rosenwald, Andreas; Rosolowski, Maciej; Schwaenen, Carsten; Sturzenhofecker, B.; Szczepanowski, Monika; Trautmann, Heiko; Wacker, H. H.; Spang, Rainer; Loeffler, Markus; Truemper, Lorenz H.; Stein, Harald; Siebert, Reiner
- Abstract
- Background: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is unclear. We used transcriptional and genomic profiling to define Burkitt's lymphoma more precisely and to distinguish subgroups in other types of mature aggressive B-cell lymphomas. Methods: We performed gene-expression profiling using Affymetrix U133A GeneChips with RNA from 220 mature aggressive B-cell lymphomas, including a core group of 8 Burkitt's lymphomas that met all World Health Organization (WHO) criteria. A molecular signature for Burkitt's lymphoma was generated, and chromosomal abnormalities were detected with interphase fluorescence in situ hybridization and array-based comparative genomic hybridization. Results: We used the molecular signature for Burkitt's lymphoma to identify 44 cases: 11 had the morphologic features of diffuse large-B-cell lymphomas, 4 were unclassifiable mature aggressive B-cell lymphomas, and 29 had a classic or atypical Burkitt's morphologic appearance. Also, five did not have a detectable IG-myc Burkitt's translocation, whereas the others contained an IG-myc fusion, mostly in simple karyotypes. Of the 176 lymphomas without the molecular signature for Burkitt's lymphoma, 155 were diffuse large-B-cell lymphomas. Of these 155 cases, 21 percent had a chromosomal breakpoint at the myc locus associated with complex chromosomal changes and an unfavorable clinical course. Conclusions: Our molecular definition of Burkitt's lymphoma clarifies and extends the spectrum of the WHO criteria for Burkitt's lymphoma. In mature aggressive B-cell lymphomas without a gene signature for Burkitt's lymphoma, chromosomal breakpoints at the myc locus were associated with an adverse clinical outcome.
- Issue Date
- 2006
- Status
- published
- Publisher
- Massachusetts Medical Soc
- Journal
- New England Journal of Medicine
- ISSN
- 0028-4793