A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma
2014 | journal article. A publication with affiliation to the University of Göttingen.
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A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma
Salaverria, I.; Martin-Guerrero, I.; Wagener, R.; Kreuz, M.; Kohler, C. W.; Richter, J. & Pienkowska-Grela, B. et al. (2014)
Blood, 123(8) pp. 1187-1198. DOI: https://doi.org/10.1182/blood-2013-06-507996
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- Authors
- Salaverria, Itziar; Martin-Guerrero, Idoia; Wagener, Rabea; Kreuz, Markus; Kohler, Christian W.; Richter, Julia; Pienkowska-Grela, Barbara; Adam, Patrick; Burkhardt, Birgit; Claviez, Alexander; Damm-Welk, Christine; Drexler, Hans G.; Hummel, Michael; Jaffe, Elaine S.; Kueppers, Ralf; Lefebvre, Christine; Lisfeld, Jasmin; Loeffler, Markus; MacLeod, Roderick A. F.; Nagel, Inga; Oschlies, Ilske; Rosolowski, Maciej; Russell, Robert B.; Rymkiewicz, Grzegorz; Schindler, Detlev; Schlesner, Matthias; Scholtysik, Rene; Schwaenen, Carsten; Spang, Rainer; Szczepanowski, Monika; Truemper, Lorenz H.; Vater, Inga; Wessendorf, Swen; Klapper, Wolfram; Siebert, Reiner
- Abstract
- The genetic hallmark of Burkitt lymphoma (BL) is the t(8;14)(q24;q32) and its variants leading to activation of the MYC oncogene. It is a matter of debate whether true BL without MYC translocation exists. Here, we identified 59 lymphomas concordantly called BL by 2 gene expression classifiers among 753 B-cell lymphomas. Only2 (3%) of these 59 molecular BL lacked a MYC translocation, which both shared a peculiar pattern of chromosome 11q aberration characterized by interstitial gains including 11q23.2-q23.3 and telomeric losses of 11q24.1-qter. We extended our analysis to 17 MYC-negative high-grade B-cell lymphomas with a similar 11q aberration and showed this aberration to be recurrently associated with morphologic and clinical features of BL. The minimal region of gain was defined by high-level amplifications in 11q23.3 and associated with overexpression of genes including PAFAH1B2 on a transcriptional and protein level. The recurrent region of loss contained a focal homozygous deletion in 11q24.2-q24.3 including the ETS1 gene, which was shown to be mutated in 4 of 16 investigated cases. These findings indicate the existence of a molecularly distinct subset of B-cell lymphomas reminiscent of BL, which is characterized by deregulation of genes in 11q.
- Issue Date
- 2014
- Status
- published
- Publisher
- Amer Soc Hematology
- Journal
- Blood
- ISSN
- 1528-0020; 0006-4971