Plasma mid-regional pro-adrenomedullin levels are inversely associated with anxiety but unrelated to depression: Results from the observational DIAST-CHF study in patients with cardiovascular risk factors
2015 | journal article. A publication with affiliation to the University of Göttingen.
Jump to: Cite & Linked | Documents & Media | Details | Version history
Cite this publication
Plasma mid-regional pro-adrenomedullin levels are inversely associated with anxiety but unrelated to depression: Results from the observational DIAST-CHF study in patients with cardiovascular risk factors
Meyer, T.; Herrmann-Lingen, C.; Chavanon, M.-L.; Pieske, B. M.; Wachter, R. R. & Edelmann, F. T. (2015)
Psychoneuroendocrinology, 62 pp. 227-232. DOI: https://doi.org/10.1016/j.psyneuen.2015.08.007
Documents & Media
Details
- Authors
- Meyer, Thomas; Herrmann-Lingen, Christoph; Chavanon, Mira-Lynn; Pieske, Burkert M.; Wachter, R. Rolf; Edelmann, Frank T.
- Abstract
- Objectives: It has been postulated that patients with heart failure have a high risk of ventricular arrhythmias and sudden cardiac death resulting from anxiety-induced autonomic arousal. In the prospective and multicenter DIAST-CHF (Diagnostic Trial on Prevalence and Clinical Course of Diastolic Dysfunction and Heart Failure) study, we therefore, tested the hypothesis that adrenomedullin (ADM), a well-established predictor for cardiovascular outcome, is associated with self-rated anxiety symptoms in patients at risk of suffering from or actually with overt heart failure. Participants and measures: Study participants with risk factors for diastolic dysfunction were requested to complete the Hospital Anxiety and Depression Scale (HADS), and plasma mid-regional proadrenomedullin (MR-proADM) concentrations were measured. Results: In bivariate analysis, we found significantly lower plasma MR-proADM levels in patients with elevated HADS-anxiety scores above the clinically relevant cut-off level of >= 11 (n=118, 536 pmol/l, interquartile range [IQR] 449-626) as compared to non-anxious study participants (n =1,292, 573 pmol/l, IQR 486-702, p = 0.001). A set of multivariate models adjusted for potential confounders confirmed the negative association between self-rated anxiety symptoms and plasma MR-proADM. In similar models, no significant association was detected between HADS-depression scores and MR-proADM. Conclusions: The inverse relationship between plasma MR-proADM and anxiety observed in patients with cardiovascular risk factors supports a previous experimental study using a mutant mouse line with a brain-specific loss of ADM expression which displayed hyperactive and over-anxious behavior. Further experimental and clinical studies are warranted to test the hypothesis that also in humans ADM acts as a neuromodulator with anxiolytic properties. (C) 2015 Published by Elsevier Ltd.
- Issue Date
- 2015
- Status
- published
- Publisher
- Pergamon-elsevier Science Ltd
- Journal
- Psychoneuroendocrinology
- ISSN
- 0306-4530