Predicting survival using clinical risk scores and non-HLA immunogenetics
2015 | journal article. A publication with affiliation to the University of Göttingen.
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Predicting survival using clinical risk scores and non-HLA immunogenetics
Balavarca, Y.; Pearce, K. F.; Norden, J.; Collin, M.; Jackson, G. H.; Holler, E. & Dressel, R. et al. (2015)
Bone Marrow Transplantation, 50(11) pp. 1445-1452. DOI: https://doi.org/10.1038/bmt.2015.173
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Details
- Authors
- Balavarca, Yesilda; Pearce, Kim F.; Norden, J.; Collin, M.; Jackson, Graham H.; Holler, Ernst; Dressel, Ralf; Kolb, H-J; Greinix, Hildegard T.; Socie, G.; Toubert, A.; Rocha, Vanderson; Gluckman, E.; Hromadnikova, Ilona; Sedlacek, Petr; Wolff, Daniel; Holtick, U.; Dickinson, Anne M.; Bickeboeller, Heike
- Abstract
- Previous studies of non-histocompatibility leukocyte antigen (HLA) gene single-nucleotide polymorphisms (SNPs) on subgroups of patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) revealed an association with transplant outcome. This study further evaluated the association of non-HLA polymorphisms with overall survival in a cohort of 762 HSCT patients using data on 26 polymorphisms in 16 non-HLA genes. When viewed in addition to an already established clinical risk score (EBMT-score), three polymorphisms: rs8177374 in the gene for MyD88-adapter-like (MAL; P = 0.026), rs9340799 in the oestrogen receptor gene (ESR; P = 0.003) and rs1800795 in interleukin-6 (IL-6; P = 0.007) were found to be associated with reduced overall survival, whereas the haplo-genotype (ACC/ACC) in IL-10 was protective (P = 0.02). The addition of these non-HLA polymorphisms in a Cox regression model alongside the EBMT-score improved discrimination between risk groups and increased the level of prediction compared with the EBMT-score alone (gain in prediction capability for EBMT-genetic-score 10.8%). Results also demonstrated how changes in clinical practice through time have altered the effects of non-HLA analysis. The study illustrates the significance of non-HLA genotyping prior to HSCT and the importance of further investigation into non-HLA gene polymorphisms in risk prediction.
- Issue Date
- 2015
- Status
- published
- Publisher
- Nature Publishing Group
- Journal
- Bone Marrow Transplantation
- ISSN
- 1476-5365; 0268-3369