Cardiovascular Risk Factors in Central Retinal Artery Occlusion Results of a Prospective and Standardized Medical Examination
2015 | journal article. A publication with affiliation to the University of Göttingen.
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Cardiovascular Risk Factors in Central Retinal Artery Occlusion Results of a Prospective and Standardized Medical Examination
Callizo, J.; Feltgen, N.; Pantenburg, S.; Wolf, A.; Neubauer, A. S.; Jurklies, B. & Wachter, R. R. et al. (2015)
Ophthalmology, 122(9) pp. 1881-1888. DOI: https://doi.org/10.1016/j.ophtha.2015.05.044
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Details
- Authors
- Callizo, Josep; Feltgen, Nicolas; Pantenburg, Stefanie; Wolf, Armin; Neubauer, Aljoscha Steffen; Jurklies, Bernhard; Wachter, R. Rolf; Schmoor, Claudia; Schumacher, Martin; Junker, Bernd; Pielen, Amelie
- Abstract
- Purpose: To analyze the underlying risk factors in patients with nonarteritic central retinal artery occlusion (CRAO) in a well-defined and homogenous group of patients enrolled in the European Assessment Group for Lysis in the Eye (EAGLE) study. Design: Analysis of the cardiovascular risk factors in a prospective, randomized clinical trial. Participants: Seventy-seven EAGLE patients with nonarteritic CRAO. Methods: Analysis of vascular risk factors and underlying diseases detected by questionnaire and standardized physical examination within 1 month after occlusion. Main Outcome Measures: The standardized physical examination included carotid Doppler ultrasonography, echocardiography, electrocardiography, blood pressure monitoring, pulse rate, urine analysis, body mass index analysis, and laboratory tests. Results: Seventy-seven of 84 patients had complete datasets for analysis. Fifty-two (67%) patients had cardiovascular risk factors in their medical history, and comprehensive phenotyping identified at least 1 new risk factor in 60 patients (78%; 95% confidence interval, 67%-87%). Thirty-one (40%) had carotid artery stenosis of at least 70%. Eleven patients experienced a stroke, 5 of those within 4 weeks after the CRAO occurred. Arterial hypertension was found in 56 (73%) patients and was newly diagnosed in 12 (16%) study participants. Cardiac diseases were also highly prevalent (22% coronary artery disease, 20% atrial fibrillation, and 17% valvular heart disease). Conclusions: Previously undiagnosed vascular risk factors were found in 78% of all CRAO patients. The most meaningful risk factor was ipsilateral carotid artery stenosis. A comprehensive and prompt diagnostic workup is mandatory for all CRAO patients. (C) 2015 by the American Academy of Ophthalmology.
- Issue Date
- 2015
- Status
- published
- Publisher
- Elsevier Science Inc
- Journal
- Ophthalmology
- ISSN
- 1549-4713; 0161-6420