Multifunctional Phosphate-Based Inorganic-Organic Hybrid Nanoparticles
2015 | journal article. A publication with affiliation to the University of Göttingen.
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Multifunctional Phosphate-Based Inorganic-Organic Hybrid Nanoparticles
Heck, J. G.; Napp, J.; Simonato, S.; Moellmer, J.; Lange, M.; Reichardt, H. M. & Staudt, R. et al. (2015)
Journal of the American Chemical Society, 137(23) pp. 7329-7336. DOI: https://doi.org/10.1021/jacs.5b01172
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Details
- Authors
- Heck, Joachim G.; Napp, Joanna; Simonato, Sara; Moellmer, Jens; Lange, Marcus; Reichardt, Holger Michael; Staudt, Reiner; Alves, Frauke ; Feldmann, Claus
- Abstract
- Phosphate-based inorganic-organic hybrid nanoparticles (IOH-NPs) with the general composition [M](2+)[R-function(O)PO3](2-) (M = ZrO, Mg2O; R = functional organic group) show multipurpose and multifunctional properties. If [R-function(O))PO3](2-) is a fluorescent dye anion ([RdyeOPO3](2-)), the IOH-NPs show blue, green, red, and near-infrared fluorescence. This is shown for [ZrO](2+)[PUP](2-), [ZrO](2+)[MFP](2-), [ZrO](2+)[RRP](2-), and [ZrO](2+)[DUT](2-) (PUP = phenylumbelliferon phosphate, MFP = methylfluorescein phosphate, RRP = resorufin phosphate, DUT = Dyomics-647 uridine triphosphate). With pharmaceutical agents as functional anions ([RdrugOPO3](2-)), drug transport and release of anti-inflammatory ([ZrO](2+)[BMP](2-)) and antitumor agents ([ZrO](2+)[FdUMP](2-)) with an up to 80% load of active drug is possible (BMP = betamethason phosphate, FdUMP = 5'-fluoro-2'-deoxyuridine 5'-monophosphate). A combination of fluorescent dye and drug anions is possible as well and shown for [ZrO](2+)[BMP](2-)(0.996)[DUT](2-)(0.004). Merging of functional anions, in general, results in [ZrO](2+)([RdrugOPO3](1-x)[RdyeOPO3](x))(2-) nanoparticles and is highly relevant for theranostics. Amine-based functional anions in [MgO](2+)[RaminePO3](2-) IOH-NPs, finally, show CO2 sorption (up to 180 mg g(-1)) and can be used for CO2/N-2 separation (selectivity up to alpha = 23). This includes aminomethyl phosphonate [AMP](2-), 1-aminoethyl phosphonate [1AEP](2-), 2-aminoethyl phosphonate [2AEP](2-), aminopropyl phosphonate [APP](2-), and aminobutyl phosphonate [ABP](2-). All [M](2+)[R-function(O)PO3](2-) IOH-NPs are prepared via noncomplex synthesis in water, which facilitates practical handling and which is optimal for biomedical application. In sum, all IOH-NPs have very similar chemical compositions but can address a variety of different functions, including fluorescence, drug delivery, and CO2 sorption.
- Issue Date
- 2015
- Status
- published
- Publisher
- Amer Chemical Soc
- Journal
- Journal of the American Chemical Society
- ISSN
- 0002-7863
- Sponsor
- Deutsche Forschungsgemeinschaft (DFG)