Comparative analysis of cerebrospinal fluid biomarkers in the differential diagnosis of neurodegenerative dementia
2016 | journal article. A publication with affiliation to the University of Göttingen.
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Comparative analysis of cerebrospinal fluid biomarkers in the differential diagnosis of neurodegenerative dementia
Llorens, F.; Schmitz, M.; Karch, A.; Cramm, M.; Lange, P.; Gherib, K. & Varges, D. A. et al. (2016)
Alzheimer s & Dementia, 12(5) pp. 577-589. DOI: https://doi.org/10.1016/j.jalz.2015.10.009
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- Authors
- Llorens, Franc; Schmitz, Matthias; Karch, Andre; Cramm, Maria; Lange, Peter; Gherib, Kerim; Varges, Daniel. A.; Schmidt, Christian D.; Zerr, Inga; Stoeck, Katharina
- Abstract
- Introduction: The analysis of cerebrospinal fluid biomarkers gains importance in clinical routine and is effective in substantiating dementia diagnosis in the differential diagnostic context. Methods: We evaluated the levels of beta-amyloid (A beta) 42, A beta 40, tau, and P-tau in a large patient population subdivided into prion diseases, tauopathies, synucleinopathies, and controls. Diagnostic test evaluation was assessed by ROC area under the curve analysis. Results: High tau levels were detected in sporadic Creutzfeldt-Jakob disease (sCJD) and high P-tau levels in Alzheimer's disease (AD) and sCJD. A beta 40 was lower exclusively in prionopathies, but low A beta 42 was detected in AD, sCJD, and Lewy body dementia. When disease groups were stratified according to the underlying proteinopathy, we detected disease-type specificities for all biomarkers. P-tau/tau, A beta 42/40, A beta 42/tau, and A beta 40/tau ratios proved valuable in discriminating disease groups and controls, especially P-tau/tau ratio in the identification of sCJD cases. Discussion: Combining the biomarker panel allows differentiating between various types of neuro-degenerative dementias and contributes to a better understanding of their pathophysiological processes. (C) 2015 Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
- Issue Date
- 2016
- Status
- published
- Publisher
- Elsevier Science Inc
- Journal
- Alzheimer s & Dementia
- ISSN
- 1552-5279; 1552-5260