Solution Structures of Hauser Base (Pr2NMgCI)-Pr-i and Turbo-Hauser Base (Pr2NMgCl)-Pr-i center dot LiCI in THE and the Influence of LiCI on the Schlenk-Equilibrium
2016 | journal article. A publication with affiliation to the University of Göttingen.
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Solution Structures of Hauser Base (Pr2NMgCI)-Pr-i and Turbo-Hauser Base (Pr2NMgCl)-Pr-i center dot LiCI in THE and the Influence of LiCI on the Schlenk-Equilibrium
Neufeld, R.; Teuteberg, T. L.; Herbst-Irmer, R. ; Mata, R. A. & Stalke, D. (2016)
Journal of the American Chemical Society, 138(14) pp. 4796-4806. DOI: https://doi.org/10.1021/jacs.6b00345
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- Authors
- Neufeld, Roman; Teuteberg, Thorsten L.; Herbst-Irmer, Regine ; Mata, Ricardo A. ; Stalke, Dietmar
- Abstract
- Grignard reagents that are at the simplest level described as "RMgX" (where R is an organic substituent and X a halide) are one of the most widely utilized classes of synthetic reagents. Lately, especially Grignard reagents with amido ligands of the type R1R2NMgX, so-called Hauser bases, and their Turbo analogue R1R2NMgX center dot LiCI play an outranging role in modern synthetic chemistry. However, because of their complex solution behavior, where Schlenk-type equilibria are involved, very little is known about their structure in solution. Especially the impact of LiCl on the Schlenk-equilibrium was still obscured by complexity and limited analytical access. Herein, we present unprecedented insights into the solution structure of the Hauser base (Pr2NMgCl)-Pr-i 1 and the Turbo -Hauser base (Pr2NMgCl)-Pr-i center dot LiCl 2 at various temperatures in THE-d(8) solution by employing a newly elaborated diffusion ordered spectroscopy (DOSY) NMR method hand-in-hand with theoretical calculations.
- Issue Date
- 2016
- Journal
- Journal of the American Chemical Society
- ISSN
- 0002-7863
- Language
- English
- Sponsor
- DNRF [DNRF93]