Impact of Structural Differences in Galactocerebrosides on the Behavior of 2D Monolayers
2016 | journal article. A publication with affiliation to the University of Göttingen.
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Impact of Structural Differences in Galactocerebrosides on the Behavior of 2D Monolayers
Stefaniu, C.; Ries, A.; Gutowski, O.; Ruett, U.; Seeberger, P. H.; Werz, D. B. & Brezesinski, G. (2016)
Langmuir, 32(10) pp. 2436-2444. DOI: https://doi.org/10.1021/acs.langmuir.5b03830
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- Authors
- Stefaniu, Cristina; Ries, Annika; Gutowski, Olof; Ruett, Uta; Seeberger, Peter H.; Werz, Daniel B.; Brezesinski, Gerald
- Abstract
- The molecular interactions of three biologically important galactocerebrosides have been studied in monolayers formed at the soft air/water interface as 2D model membranes. Highly surface-sensitive techniques as GIXD (grazing incidence X-ray diffraction), IRRAS (infrared reflection absorption spectroscopy), and BAM (Brewster angle microscopy) have been used. The study reveals that small differences in the chemical structure have a relevant impact on the physical chemical properties and intermolecular interactions. The presence of a 2-D-hydroxyl group in the fatty acid favored for GalCer C24:0 (2-0H) monolayers a higher hydration state of the headgroup at low lateral pressures (<25 mN/m) and a higher condensation effect above 30 mN/m. An opposite behavior was recorded for GalCer 024:0 and GalCer C24:1, for which the intermolecular interactions are defined by the weakly hydrated but strong H-bonded interconnected head groups. Additionally, the 15-cis-double bond in the fatty acid chain (nervonic acid) of GalCer C24:1 stabilized the LE phase but did not disturb the packing parameters of the LC phase as compared with the saturated compound GalCer C24:0.
- Issue Date
- 2016
- Status
- published
- Publisher
- Amer Chemical Soc
- Journal
- Langmuir
- ISSN
- 0743-7463