Modulation of CNS autoimmune responses by CD8(+) T cells coincides with their oligoclonal expansion
2016 | journal article. A publication with affiliation to the University of Göttingen.
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Modulation of CNS autoimmune responses by CD8(+) T cells coincides with their oligoclonal expansion
Fischer, H. J.; van den Brandt, J.; Lingner, T.; Odoardi, F. ; Fluegel, A.; Weishaupt, A. & Reichardt, H. M. (2016)
Journal of Neuroimmunology, 290 pp. 26-32. DOI: https://doi.org/10.1016/j.jneuroim.2015.10.020
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- Authors
- Fischer, Henrike J.; van den Brandt, Jens; Lingner, Thomas; Odoardi, Francesca ; Fluegel, Alexander; Weishaupt, Andreas; Reichardt, Holger Michael
- Abstract
- MS is a highly prevalent neuroinflammatory disease of presumed autoimmune origin. Clinical observations and animal studies suggest that CD8(+) T cells play an important role in MS but their exact mechanisms are ill defined. When we actively induced EAE in CD8 knock-out DA rats, or adoptively transferred encephalitogenic CD4(+) T cells into CD8 knock-out DA rats, the disease course was indistinguishable from controls. Since our previous findings had revealed that the absence of CD8(+) T cells in Lewis rats ameliorated EAE, we compared antigen-induced T cell differentiation in both strains. Disease onset and the composition of the draining lymph nodes were similar but T cell activation in DA rats was much weaker. Moreover, oligoclonal expansion of CD8(+) T cells was exclusively observed in Lewis but not in DA rats. This suggests that myelin-specific CD8(+) T cells are involved in the differentiation of encephalitogenic CD4(+) T cells in Lewis rats, whilst they do not impact CD4(+) T cell priming in DA rats. Hence, clonal expansion of CD8(+) T cells in secondary lymphoid organs appears to be linked to their ability to modulate CNS autoimmune responses. (C) 2015 Published by Elsevier B.V.
- Issue Date
- 2016
- Status
- published
- Publisher
- Elsevier Science Bv
- Journal
- Journal of Neuroimmunology
- ISSN
- 1872-8421; 0165-5728
- Sponsor
- German Research Foundation (DFG) [SFB/TRR 43]