Toward modeling locomotion using electromyography-informed 3D models: application to cerebral palsy
2017 | journal article. A publication with affiliation to the University of Göttingen.
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Toward modeling locomotion using electromyography-informed 3D models: application to cerebral palsy
Sartori, M. ; Fernandez, J. W.; Modenese, L.; Carty, C. P.; Barber, L. A.; Oberhofer, K. & Zhang, J. et al. (2017)
Wiley Interdisciplinary Reviews Systems Biology and Medicine, 9(2) art. e1368. DOI: https://doi.org/10.1002/wsbm.1368
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- Authors
- Sartori, Massimo ; Fernandez, J. W.; Modenese, L.; Carty, Christopher P.; Barber, L. A.; Oberhofer, K.; Zhang, J.; Handsfield, G. G.; Stott, N. S.; Besier, Thor F.; Farina, Dario ; Lloyd, David G.
- Abstract
- This position paper proposes a modeling pipeline to develop clinically relevant neuromusculoskeletal models to understand and treat complex neurological disorders. Although applicable to a variety of neurological conditions, we provide direct pipeline applicative examples in the context of cerebral palsy (CP). This paper highlights technologies in: (1) patient-specific segmental rigid body models developed from magnetic resonance imaging for use in inverse kinematics and inverse dynamics pipelines; (2) efficient population-based approaches to derive skeletal models and muscle origins/insertions that are useful for population statistics and consistent creation of continuum models; (3) continuum muscle descriptions to account for complex muscle architecture including spatially varying material properties with muscle wrapping; (4) muscle and tendon properties specific to CP; and (5) neural-based electromyography-informed methods for muscle force prediction. This represents a novel modeling pipeline that couples for the first time electromyography extracted features of disrupted neuromuscular behavior with advanced numerical methods for modeling CP-specific musculoskeletal morphology and function. The translation of such pipeline to the clinical level will provide a new class of biomarkers that objectively describe the neuromusculoskeletal determinants of pathological locomotion and complement current clinical assessment techniques, which often rely on subjective judgment. (C) 2016 Wiley Periodicals, Inc.
- Issue Date
- 2017
- Status
- published
- Publisher
- Wiley
- Journal
- Wiley Interdisciplinary Reviews Systems Biology and Medicine
- ISSN
- 1939-005X; 1939-5094