meta-C-H Bromination on Purine Bases by Heterogeneous Ruthenium Catalysis
2017 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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meta-C-H Bromination on Purine Bases by Heterogeneous Ruthenium Catalysis
Warratz, S. ; Burns, D. J.; Zhu, C.; Korvorapun, K. ; Rogge, T. ; Scholz, J. & Jooss, C. et al. (2017)
Angewandte Chemie International Edition, 56(6) pp. 1557-1560. DOI: https://doi.org/10.1002/anie.201609014
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Details
- Authors
- Warratz, Svenja ; Burns, David J.; Zhu, Cuiju; Korvorapun, Korkit ; Rogge, Torben ; Scholz, Julius ; Jooss, Christian ; Gelman, Dmitri; Ackermann, Lutz
- Abstract
- Methods for positionally selective remote C-H functionalizations are in high demand. Herein, we disclose the first heterogeneous ruthenium catalyst for meta-selective C-H functionalizations, which enabled remote halogenations with excellent site selectivity and ample scope. The versatile heterogeneous Ru@SiO2 catalyst was broadly applicable and could be easily recovered and reused, which set the stage for the direct fluorescent labeling of purines. In contrast to palladium, rhodium, iridium, or cobalt complexes, solely the ruthenium catalysis manifold provided access to meta-halogenated purine derivatives, illustrating the unique power of ruthenium C-H activation catalysis.
- Issue Date
- 2017
- Journal
- Angewandte Chemie International Edition
- Project
- SFB 1073: Kontrolle von Energiewandlung auf atomaren Skalen
SFB 1073 | Topical Area C | C01 Hydrid-Anordnungen für die Untersuchung photo-induzierter mehrstufiger katalytischer Prozesse - Organization
- Institut für Materialphysik
- ISSN
- 1521-3773; 1433-7851