Metabolites from the Endophytic Fungus Curvularia sp M12 Act as Motility Inhibitors against Phytophthora capsici Zoospores
2017 | journal article. A publication with affiliation to the University of Göttingen.
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Metabolites from the Endophytic Fungus Curvularia sp M12 Act as Motility Inhibitors against Phytophthora capsici Zoospores
Mondol, M. A. M.; Farthouse, J.; Islam, M. T.; Schueffler, A. & Laatsch, H. (2017)
Journal of Natural Products, 80(2) pp. 347-355. DOI: https://doi.org/10.1021/acs.jnatprod.6b00785
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Details
- Authors
- Mondol, Muhammad Abdul Mojid; Farthouse, Jannatul; Islam, Mohammad Tofazzal; Schueffler, Anja; Laatsch, Hartmut
- Abstract
- The endophytic fungus Curvularia sp., strain M12, was isolated from a leaf of the medicinal plant Murraya koenigii and cultured on rice medium followed by chemical screening of the culture extract. Chromatographic analysis led to the isolation of four new compounds, murranofuran A (1), murranolide A (2), murranopyrone (3a), and murranoic acid A (4a), along with six known metabolites, N-(2-hydroxy-6-methoxyphenyl)acetamide (5), curvularin (6), (S)-dehydrocurvularin (7), pyrenolide A (8), modiolide A (9), and 8-hydroxy-6-methoxy-3-methylisocoumarin (10). The structures of the known compounds were confirmed by comparing ESI HR mass spectra, H-1 and C-13 NMR, and optical rotation data with values reported in the literature. The planar structures of the hew compounds were elucidated by extensive analysis of 1D and 2D NMR and mass data. The absolute configurations of the new compounds were established by coupling constant analysis, modified Mosher's method, and CD data. Compound 8 showed a strong motility impairing activity against Phytophthora capsici zoospores at a low concentration (100% at 0.5 mu g/mL) in a short time (30 min). Compounds 2, 3a, 6, 7, 9, and 10 exhibited zoospore motility impairment activity at higher concentrations (IC50: 50-100 mu g/mL).
- Issue Date
- 2017
- Status
- published
- Publisher
- Amer Chemical Soc
- Journal
- Journal of Natural Products
- ISSN
- 1520-6025; 0163-3864
- Sponsor
- Alexander von Humboldt Foundation; World Bank [2071]