Histopathology and Florbetaben PET in Patients Incorrectly Diagnosed with Alzheimer's Disease
2017 | journal article. A publication with affiliation to the University of Göttingen.
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Histopathology and Florbetaben PET in Patients Incorrectly Diagnosed with Alzheimer's Disease
Sabbagh, M. N.; Anand, K.; Richards, D.; Murayama, S.; Akatsu, H.; Takao, M. & Rowe, C. C. et al. (2017)
Journal of Alzheimer's Disease, 56(2) pp. 441-446. DOI: https://doi.org/10.3233/JAD-160821
Documents & Media
Details
- Authors
- Sabbagh, Marwan N.; Anand, Keshav; Richards, Danielle; Murayama, Shigeo; Akatsu, Hiroyasu; Takao, Masaki; Rowe, Christopher C.; Masters, Colin L.; Barthel, Henryk; Gertz, Hermann-Josef; Peters, Oliver; Rasgon, Natalie; Jovalekic, Aleksandar; Sabri, Osama; Schulz-Schaeffer, Walter J. ; Seibyl, John; Schäuble, Barbara
- Abstract
- Of 57 individuals diagnosed with Alzheimer's disease (AD) in a phase III study, 13 (23%) had amyloid-beta (A beta) levels on postmortem histopathology that did not explain the dementia. Based on postmortem histopathology, a wide range of different non-AD conditions was identified, including frontotemporal dementia, hippocampal sclerosis, and dementia with Lewy bodies. Of the histopathologically A beta negative scored cases ante-mortem Florbetaben PET scans were classified as negative for A beta in 11 patients based on visual analysis and in all 12 quantifiable cases based on composite standardized uptake value ratios. Thus, florbetaben PET can assist physicians in the differential diagnosis of neurodegenerative disorders by reliably excluding A beta pathology.
- Issue Date
- 2017
- Status
- published
- Publisher
- Ios Press
- Journal
- Journal of Alzheimer's Disease
- ISSN
- 1387-2877
- eISSN
- 1875-8908
- ISSN
- 1875-8908; 1387-2877
