The Significance of the Late Na+ Current for Arrhythmia Induction and the Therapeutic Antiarrhythmic Potential of Ranolazine
2017 | journal article; overview. A publication with affiliation to the University of Göttingen.
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The Significance of the Late Na+ Current for Arrhythmia Induction and the Therapeutic Antiarrhythmic Potential of Ranolazine
Mason, F. E. & Sossalla, S. (2017)
Journal of Cardiovascular Pharmacology and Therapeutics, 22(1) pp. 40-50. DOI: https://doi.org/10.1177/1074248416644989
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- Authors
- Mason, Fleur E. ; Sossalla, Samuel
- Abstract
- The purpose of this article is to review the basis of arrhythmogenesis, the functional and clinical role of the late Na current, and its therapeutic inhibition. Under pathological conditions such as ischemia and heart failure this current is abnormally enhanced and influences cellular electrophysiology as a proarrhythmic substrate in myocardial pathology. Ranolazine the only approved late Na current blocker has been demonstrated to produce antiarrhythmic effects in the atria and the ventricle. We summarize recent experimental and clinical studies of ranolazine and other experimental late Na current blockers and discuss the significance of the available data.
- Issue Date
- 2017
- Journal
- Journal of Cardiovascular Pharmacology and Therapeutics
- Project
- SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz
SFB 1002 | A03: Bedeutung CaMKII-abhängiger Mechanismen für die Arrhythmogenese bei Herzinsuffizienz - Working Group
- RG Sossalla (Kardiovaskuläre experimentelle Elektrophysiologie und Bildgebung)
- ISSN
- 1940-4034; 1074-2484
- Language
- English