Heart fatty acid binding protein as a potential diagnostic marker for neurodegenerative diseases
2004 | journal article. A publication with affiliation to the University of Göttingen.
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Heart fatty acid binding protein as a potential diagnostic marker for neurodegenerative diseases
Steinacker, P.; Mollenhauer, B.; Bibl, M.; Cepek, L.; Esselmann, H.; Brechlin, P. & Lewczuk, P. et al. (2004)
Neuroscience Letters, 370(1) pp. 36-39. DOI: https://doi.org/10.1016/j.neulet.2004.07.061
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Details
- Authors
- Steinacker, Petra; Mollenhauer, Brit; Bibl, Mirko; Cepek, L.; Esselmann, Herrmann; Brechlin, Peter; Lewczuk, Piotr; Poser, Sigrid; Kretzschmar, Hans A.; Wiltfang, J.; Trenkwalder, Claudia; Otto, Markus
- Abstract
- The diagnosis of neurodegenerative diseases with demential requires several different test approaches and often remains uncertain. Using a proteomic approach it was shown in nine patients that heart fatty acid binding protein (H-FABP) might be a biomarker for Creutzfeldt-Jakob disease (CJD). The aim of our study was to evaluate whether H-FABP is a biomarker for the differential diagnosis of dementias. Therefore we measured H-FABP in cerebrospinal fluid (CSF) and serum of patients having CJD, dementia with Lewy-bodies (DLB), Alzheimer's disease (AD) and in non-demented control (NDC) patients. H-FABP levels in CSF and serum of CJD patients are increased compared to non-demented controls. Levels of H-FABP were significantly higher in CJD patients compared to AD and DLB in CSF. However, discrimination between CJD and AD was not possible in serum. Interestingly, highest levels of H-FABP were found in serum of DLB patients. Our results suggest that H-FABP might be a useful biomarker for the differentiation between the dementias examined if levels in CSF and serum are determined in parallel. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
- Issue Date
- 2004
- Status
- published
- Publisher
- Elsevier Sci Ireland Ltd
- Journal
- Neuroscience Letters
- ISSN
- 0304-3940