XGRIP2.1 is encoded by a vegetally localizing, matemal mRNA and functions in germ cell development and anteroposterior PGC positioning in Xenopus laevis
2007 | journal article. A publication with affiliation to the University of Göttingen.
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XGRIP2.1 is encoded by a vegetally localizing, matemal mRNA and functions in germ cell development and anteroposterior PGC positioning in Xenopus laevis
Tarbashevich, K.; Koebemick, K. & Pieler, T. (2007)
Developmental Biology, 311(2) pp. 554-565. DOI: https://doi.org/10.1016/j.ydbio.2007.09.012
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- Authors
- Tarbashevich, Katsiaryna; Koebemick, Katja ; Pieler, Tomas
- Abstract
- The Xenopus germ line is derived from a specialized region in the vegetal hemisphere of the oocyte, the germ plasm. Several maternal transcripts harboured in this region have been connected to the process of germ cell specification. We identified and functionally characterized a novel vegetally localizing mRNA encoding a glutamate receptor interacting protein (GRIP) family member in Xenopus, termed XGRIP2.1. XGRIP2.1 is specifically associated with the germ plasm and PGCs throughout Xenopus embryogenesis. Morpholino-mediated knockdown and overexpression of a putative dominant negative XGRIP2.1 protein fragment reduced average PGC numbers and interfered with the proper anteroposterior positioning of PGCs at tailbud stages. Thus, our results suggest that XGRIP2.1 is required for normal PGC development and migration in Xenopus. (c) 2007 Elsevier Inc. All rights reserved.
- Issue Date
- 2007
- Status
- published
- Publisher
- Academic Press Inc Elsevier Science
- Journal
- Developmental Biology
- ISSN
- 0012-1606