Metabolic gene polymorphisms and lung cancer risk in non-smokers - An update of the GSEC study
2005 | conference paper. A publication with affiliation to the University of Göttingen.
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Metabolic gene polymorphisms and lung cancer risk in non-smokers - An update of the GSEC study
Raimondi, S.; Boffetta, P.; Anttila, S.; Brockmoeller, J.; Butkiewicz, D.; Cascorbi, I. & Clapper, M. L. et al. (2005)
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 592(1-2) pp. 45-57. Satellite Meeting on Linking Toxicology to Epidemiology - Biomarkers and New Technologies, Haikko, FINLAND.
Amsterdam: Elsevier Science Bv. DOI: https://doi.org/10.1016/j.mrfmmm.2005.06.002
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Details
- Authors
- Raimondi, S.; Boffetta, P.; Anttila, S.; Brockmoeller, Juergen; Butkiewicz, D.; Cascorbi, I.; Clapper, M. L.; Dragani, T. A.; Garte, S.; Gsur, A.; Haidinger, G.; Hirvonen, A.; Ingelman-Sundberg, M.; Kalina, I.; Lan, Q.; Leoni, V. P.; Le Marchand, L.; London, S. J.; Neri, M.; Povey, A. C.; Rannug, A.; Reszka, E.; Ryberg, D.; Risch, Angela; Romkes, M.; Ruano-Ravina, A.; Schoket, B.; Spinola, M.; Sugimura, H.; Wu, X.; Taioli, E.
- Abstract
- Background: Since genetic factors may play an important role in lung cancer development at low dose carcinogen exposure, non-smokers are a good model to study genetic susceptibility and its interaction with environmental factors. Materials and methods: We evaluated the role of the metabolic gene polymorphisms CYP1A1MsPI, CYP1A11le(462) Val, GSTM1, and GSTT1 in non-smoker lung cancer patients from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC). Non-smokers (defined as subjects who never smoked on a regular basis) were selected from the GSEC database. We pooled the raw data from 21 case-control studies for a total of 2764 Caucasians (555 cases and 2209 controls) and 383 Asians (113 cases and 270 controls). Tests of heterogeneity and of inclusion bias were performed. Results: A significant association between lung cancer and CYP1A11le(462)Val polymorphism was observed in Caucasians (adjusted OR= 2.04, 95% Cl 1.17-3.54). GSTT1 deletion seems to be a risk factor for lung cancer in Caucasian non smokers only when the analysis was restricted to studies including healthy controls (adjusted OR= 1.66, 95% Cl 1.12-2.46). A protective effect on lung cancer was observed with the combination of CYP1A1 wild type, GSTM1 null, and GSTT1 non-null genotypes. None of the analysed polymorphisms were associated with lung cancer in Asian non-smokers. Discussion: Our analysis confirms previous findings that CYP1A11le(462) Val polymorphism may play a role in lung carcinogenesis in Caucasian non-smokers. (c) 2005 Elsevier B.V. All rights reserved.
- Issue Date
- 2005
- Status
- published
- Publisher
- Elsevier Science Bv
- Journal
- Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- Conference
- Satellite Meeting on Linking Toxicology to Epidemiology - Biomarkers and New Technologies
- Conference Place
- Haikko, FINLAND
- ISSN
- 0027-5107