Normal hypocretin-1 (orexin-A) levels in the cerebrospinal fluid of patients with Huntington's disease
2005 | journal article. A publication with affiliation to the University of Göttingen.
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Normal hypocretin-1 (orexin-A) levels in the cerebrospinal fluid of patients with Huntington's disease
Meier, A.; Mollenhauer, B.; Cohrs, S.; Rodenbeck, A.; Jordan, W.; Meller, J. & Otto, M. (2005)
Brain Research, 1063(2) pp. 201-203. DOI: https://doi.org/10.1016/j.brainres.2005.09.028
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Details
- Authors
- Meier, A.; Mollenhauer, Brit; Cohrs, Stefan; Rodenbeck, Andrea; Jordan, W.; Meller, J.; Otto, Markus
- Abstract
- A significant atrophy and loss of hypocretin neurons in the brains of human patients with Huntington's disease (HD) and in R6/2 mice have been reported. We included 10 patients with HD and 12 patients with chorea-like hyperkinetic movement disorders (non-HD). All patients of the HD group and eleven patients of the non-HD group showed normal hypocretin-1 levels. Thus, hypocretin-1 may not serve as an additional diagnostic marker for HD. (C) 2005 Elsevier B.V. All rights reserved.
- Issue Date
- 2005
- Status
- published
- Publisher
- Elsevier Science Bv
- Journal
- Brain Research
- ISSN
- 0006-8993
