Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD
2007 | journal article. A publication with affiliation to the University of Göttingen.
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Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD
Asherson, P.; Brookes, K.; Franke, B.; Chen, W.; Gill, M.; Ebstein, R. P. & Buitelaar, J. K. et al. (2007)
American Journal of Psychiatry, 164(4) pp. 674-677. DOI: https://doi.org/10.1176/appi.ajp.164.4.674
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Details
- Authors
- Asherson, Philip; Brookes, Keeley; Franke, Barbara; Chen, Wai; Gill, Michael; Ebstein, Richard P.; Buitelaar, J. K.; Banaschewski, Tobias; Sonuga-Barke, Edmund J.; Eisenberg, Jacques; Manor, Iris; Miranda, Ana; Oades, Robert D.; Roeyers, Herbert; Rothenberger, Aribert; Sergeant, Joseph; Steinhausen, Hans-Christoph; Faraone, Steven V.
- Abstract
- Objective: The primary purpose of this study was to confirm the association of a specific haplotype of the dopamine transporter gene and attention deficit hyperactivity disorder (ADHD), which could be one source of the heterogeneity seen across published studies. Method: The authors previously reported the association of ADHD with a subgroup of chromosomes containing specific alleles of two variable-number tandem repeat polymorphisms within the 3' untranslated region and intron 8 of the dopamine transporter gene. They now report on this association in a sample of ADHD combined-type probands. Results: The original observations were confirmed, with an overall odds ratio of 1.4 across samples. Conclusions: These data challenge results of meta-analyses suggesting that dopamine transporter variation does not have an effect on the risk for ADHD, and they indicate that further investigation of functional variation in the gene is required.
- Issue Date
- 2007
- Status
- published
- Publisher
- Amer Psychiatric Publishing, Inc
- Journal
- American Journal of Psychiatry
- ISSN
- 1535-7228; 0002-953X
- Sponsor
- NIMH NIH HHS [R01MH62873]