A paediatric supratentorial primitive neuroectodermal tumour associated with malignant astrocytic transformation and a clonal origin of both components
2007 | conference paper. A publication with affiliation to the University of Göttingen.
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A paediatric supratentorial primitive neuroectodermal tumour associated with malignant astrocytic transformation and a clonal origin of both components
Kuhn, S. A.; Hanisch, U.-K.; Ebmeier, K.; Beetz, C.; Brodhun, M.; Reichart, R. & Ewald, C. et al. (2007)
Neurosurgical Review, 30(2) pp. 143-149. 56th Annual Meeting of the German-Society-of-Neurosurgery, Strasbourg, GERMANY.
New york: Springer. DOI: https://doi.org/10.1007/s10143-007-0069-5
Documents & Media
Details
- Authors
- Kuhn, Susanne Antje; Hanisch, Uwe-Karsten; Ebmeier, Kristian; Beetz, Christian; Brodhun, Michael; Reichart, Rupert; Ewald, Christian; Deufel, Thomas; Kalff, Rolf
- Abstract
- The case of a 7-year-old boy suffering from a supratentorial primitive neuroectodermal tumour (sPNET) at the age of 5 is presented. The tumour has been characterized by astrocytic areas within the sPNET revealing malignant transformation up to a multiform glioblastoma during the course of the disease. The clonal origin of both tumour components was established by loss of heterozygosity (LOH) analysis. Clinically, the tumour showed an aggressive biological behaviour with two recurrences. We discuss this very rare case and the first description of the clonal origin of distinct and distinguishable tumour components taking into consideration published literature.
- Issue Date
- 2007
- Status
- published
- Publisher
- Springer
- Journal
- Neurosurgical Review
- Conference
- 56th Annual Meeting of the German-Society-of-Neurosurgery
- Conference Place
- Strasbourg, GERMANY
- ISSN
- 0344-5607
