Effects of transcranial direct current stimulation coupled with repetitive electrical stimulation on cortical spreading depression
2007 | journal article. A publication with affiliation to the University of Göttingen.
Jump to: Cite & Linked | Documents & Media | Details | Version history
Cite this publication
Effects of transcranial direct current stimulation coupled with repetitive electrical stimulation on cortical spreading depression
Fregni, F.; Liebetanz, D.; Monte-Silva, K. K.; Oliveira, M. B.; Santos, A. A.; Nitsche, M. A. & Pascual-Leone, A. et al. (2007)
Experimental Neurology, 204(1) pp. 462-466. DOI: https://doi.org/10.1016/j.expneurol.2006.09.019
Documents & Media
Details
- Authors
- Fregni, Felipe; Liebetanz, David; Monte-Silva, Katia K.; Oliveira, Manuella B.; Santos, Angela A.; Nitsche, Michael A.; Pascual-Leone, Alvaro; Guedes, Rubem C. A.
- Abstract
- We have recently shown that two techniques of brain stimulation - repetitive electrical stimulation (ES) (that mimics transcranial magnetic stimulation) and transcranial direct current stimulation (tDCS) - modify the velocity of cortical spreading depression (CSD) significantly. Herein we aimed to study the effects of these two techniques combined on CSD. Thirty-two Wistar rats were divided into four groups according to the treatment: sham tDCS/sham ES, sham tDCS/1 Hz ES, anodal tDCS/1 Hz ES, cathodal tDCS/1 Hz ES. Our findings show that 1 Hz ES reduced CSD velocity, and this effect was modified by either anodal or cathodal tDCS. Anodal tDCS induced larger effects than cathodal tDCS. Hereby CSD velocity was actually increased significantly after anodal tDCS/1 Hz ES. Our results show that combining two techniques of brain stimulation can modify significantly the effects of ES alone on cortical excitability as measured by the neurophysiological parameter of cortical spreading depression and therefore provide important insights into the effects of this new approach of brain stimulation on cortical activity. (c) 2006 Elsevier Inc. All rights reserved.
- Issue Date
- 2007
- Status
- published
- Publisher
- Academic Press Inc Elsevier Science
- Journal
- Experimental Neurology
- ISSN
- 0014-4886
- Sponsor
- NHLBI NIH HHS [K30 HL04095-03]