Widespread demyelination in the cerebellar cortex in multiple sclerosis
2007 | Zeitschriftenartikel. Eine Publikation mit Affiliation zur Georg-August-Universität Göttingen.
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Zitiervorschlag
Widespread demyelination in the cerebellar cortex in multiple sclerosis
Kutzelnigg, A.; Faber-Rod, J. C.; Bauer, J.; Lucchinetti, C. F.; Sorensen, P. S.; Laursen, H. & Stadelmann, C. u.a. (2007)
Brain Pathology, 17(1) pp. 38-44. DOI: https://doi.org/10.1111/j.1750-3639.2006.00041.x
Dokumente & Medien
Details
- Autor(en)
- Kutzelnigg, Alexandra; Faber-Rod, Jens C.; Bauer, Jan; Lucchinetti, Claudia F.; Sorensen, Per Soelberg; Laursen, Henning; Stadelmann, Christine ; Brueck, Wolfgang; Rauschka, Helmut; Schmidbauer, Manfred; Lassmann, Hans
- Zusammenfassung
- Neocortical demyelination in the forebrain has recently been identified as an important pathological feature of multiple sclerosis (MS). Here we describe that the cerebellar cortex is a major predilection site for demyelination, in particular in patients with primary and secondary progressive MS. In these patients, on average, 38.7% of cerebellar cortical area is affected, reaching in extreme examples up to 92%. Cerebellar cortical demyelination occurs mainly in a band-like manner, affecting multiple folia. The lesions are characterized by primary demyelination with relative axonal and neuronal preservation, although some axonal spheroids and a moderate reduction of Purkinje cells are present. Although cortical demyelination sometimes occurs together with demyelination in the adjacent white matter (leukocortical lesions), in most instances, the cortex was affected independently from white matter lesions. We found no correlation between demyelination in the cortex and the white matter, and in some cases, extensive cortical demyelination was present in the near absence of white matter lesions. Our data identify cortical demyelination as a potential substrate of cerebellar dysfunction in MS.
- Erscheinungsdatum
- 2007
- Status
- published
- Herausgeber
- Blackwell Publishing
- Zeitschrift
- Brain Pathology
- ISSN
- 1015-6305