Tauopathies and synucleinopathies: Do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis?
2007 | journal article. A publication with affiliation to the University of Göttingen.
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Tauopathies and synucleinopathies: Do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis?
Mollenhauer, B.; Bibl, M.; Esselmann, H.; Steinacker, P.; Trenkwalder, C.; Wiltfang, J. & Otto, M. (2007)
Journal of Neural Transmission, 114(7) pp. 919-927. DOI: https://doi.org/10.1007/s00702-007-0629-4
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- Authors
- Mollenhauer, Brit; Bibl, Mirko; Esselmann, Herrmann; Steinacker, Petra; Trenkwalder, Claudia; Wiltfang, J.; Otto, Markus
- Abstract
- To evaluate variations in amyloid beta (A beta) peptide pattern in cerebrospinal fluid (CSF) in neurodegenerative disorders. A recently estabfished quantitative urea-based A beta-sodium-dodecylsulfate-polyacrylamide-gel-electrophoresis with western immunoblot (AP-SDS-PAGE/immunoblot) revealed a highly conserved A beta peptide (A beta 1-37, 1-38, 1-39, 1-40, 1-42) pattern in CSF. We asked whether the variation might be useful to further elucidate the overlap between or distinctions among neurodegenerative diseases in A beta-processing. We used the A beta-SDS-PAGE/immunoblot to investigate CSF for diseasespecific A beta peptide patterns. CSF samples from 96 patients with mainly clinically diagnosed Alzheimer's disease (n = 15), progressive supranuclear palsy (n = 20), corticobasal degeneration (n =: 12), Parkinson's disease (n = 11), multiple systems atrophy (n = 18), and dementia with Lewy-bodies (n = 20) were analysed as well a comparison group (n = 19). The A beta peptide patterns varied between tauopathies and synucleinopathies and between all diseases and the comparison group, possibly due to the influence of tau and a-synuctein on Ap-processing.
- Issue Date
- 2007
- Status
- published
- Publisher
- Springer
- Journal
- Journal of Neural Transmission
- ISSN
- 0300-9564