The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype
2008 | journal article. A publication with affiliation to the University of Göttingen.
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The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype
Vockerodt, M.; Morgan, S. L.; Kuo, M.; Wei, W.; Chukwuma, M. B.; Arrand, J. R. & Kube, D. et al. (2008)
The Journal of Pathology, 216(1) pp. 83-92. DOI: https://doi.org/10.1002/path.2384
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- Authors
- Vockerodt, Martina; Morgan, S. L.; Kuo, M.; Wei, W.; Chukwuma, M. B.; Arrand, John R.; Kube, Dieter; Gordon, Jennifer; Young, L. S.; Woodman, Ciaran B.; Murray, Paul G.
- Abstract
- Although the latent membrane protein-1 (LMP1) of the Epstein-Barr virus (EBV) is believed to be important for the transformation of germinal centre (GC) B cells, the precise contribution of this viral oncogene to lymphoma development is poorly understood. In this study, we used a non-viral vector-based method to express LMP1 in primary human GC B cells. Gene expression profiling revealed that LMP1 induced in GC B cells transcriptional changes characteristic of Hodgkin's lymphoma cell lines. Strikingly, LMP1 down-regulated the expression of B-cell-specific genes including B-cell receptor components such as CD79A, CD79B, CD19, CD20, CD22, and BLNK. LMP1 also induced the expression of ID2, a negative regulator of B-cell differentiation. Our data suggest that in EBV-positive cases, LMP1 is likely to be a major contributor to the altered transcriptional pattern characteristic of Hodgkin/Reed-Sternberg cells, including the loss of B-cell identity. Copyright (C) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
- Issue Date
- 2008
- Status
- published
- Publisher
- John Wiley & Sons Ltd
- Journal
- The Journal of Pathology
- ISSN
- 0022-3417