Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice
2008 | journal article. A publication with affiliation to the University of Göttingen.
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- Authors
- Cotel, Marie-Caroline; Bayer, Thomas A.; Wirths, Oliver
- Abstract
- Loss of neurons in the hippocampus and other brain regions is, besides the occurrence of plaques and tangles, a neuropathological feature of Alzheimer's disease (AD). In recent years a plethora of transgenic mouse models overexpressing mutant amyloid precursor protein (APP) has been developed, which represent valuable research tools. Whereas extracellular plaque pathology is a common feature of these models, neuronal loss is a rather rare characteristic. In the present study, we quantified the number of neurons in the dentate gyrus granule layer (GCL) in 2- and 12-month-old APP/PS1KI mice, a mouse model that has been previously shown to have significant loss of neurons in the CA1 layer of the hippocampus. Stereological analysis revealed a strongly significant decrease of GCLs in aged APP/PS1KI mice, compared to age-matched PS1KI control animals (-44%), however, the volume of the GCL was not different. (C) 2008 Elsevier B.V. All rights reserved.
- Issue Date
- 2008
- Status
- published
- Publisher
- Elsevier Science Bv
- Journal
- Brain Research
- ISSN
- 0006-8993