Family-based association study of the MTHFR polymorphism C677T in patients with nonsyndromic cleft lip and palate from Central Europe
2008 | journal article. A publication with affiliation to the University of Göttingen.
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Family-based association study of the MTHFR polymorphism C677T in patients with nonsyndromic cleft lip and palate from Central Europe
Reutter, H.; Birnbaum, S.; Lacava, A. D.; Mende, M.; Henschke, H.; Bergé, S. & Braumann, B. et al. (2008)
The Cleft Palate-Craniofacial Journal, 45(3) pp. 267-271. DOI: https://doi.org/10.1597/06-174
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Details
- Authors
- Reutter, Heiko; Birnbaum, Stefanie; Lacava, Amalia Diaz; Mende, Meinhard; Henschke, Henning; Bergé, Stefaan; Braumann, Bert; Lauster, Carola; Schiefke, Franziska; Wenghoefer, Matthias; Saffar, Mitra; Reich, Rudolf H.; Scheer, Martin; Kramer, Franz-Josef; Knapp, Michael; Mangold, Elisabeth
- Abstract
- Objective: The 677C -> T allele in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has been implicated in the etiology of nonsyndromic cleft lip and palate (CL/P). This study involved a family-based association study of the MTHFR polymorphism. Patients/Participants: We examined 181 patients with CUP of central European descent and their parents for this variant. Results: The transmission disequilibrium test (TDT) did not confirm an association between the MTHFR 677C -> T polymorphism and nonsyndromic CUP as previously suggested (p = .36). When comparing the offspring of mothers with periconceptional use of folate to those without, no statistically significant differences were found (p = .708). Conclusion: Our data suggest that the MTHFR 677C -> T polymorphism does not make a major contribution to the occurrence of CUP among central Europeans.
- Issue Date
- 2008
- Journal
- The Cleft Palate-Craniofacial Journal
- ISSN
- 1055-6656
