Influence of farnesol on the morphogenesis of Aspergillus niger
2008 | journal article. A publication with affiliation to the University of Göttingen.
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Influence of farnesol on the morphogenesis of Aspergillus niger
Lorek, J.; Poeggeler, S.; Weide, M. R.; Breves, R. & Bockmuehl, D. P. (2008)
Journal of Basic Microbiology, 48(2) pp. 99-103. DOI: https://doi.org/10.1002/jobm.200700292
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- Authors
- Lorek, Justine; Poeggeler, Stefanie; Weide, Mirko R.; Breves, Roland; Bockmuehl, Dirk P.
- Abstract
- Farnesol was the first quorum-sensing regulator to be found in eukaryotic cells. In Candida albicans, a dimorphic fungal human pathogen, farnesol blocks the yeast-to-filamentous growth transition. Here we show that in Aspergillus niger farnesol acts as an inhibitor of conidiation: Colonies grown on media containing farnesol were unable to develop conidia. Although farnesol treated A. niger cultures exhibited a colony morphology resembling the "fluffy" phenotype of A. nidulans, which is caused by a hyperactive G-protein/cAMP pathway, the intracellular level of cAMP in A. niger mycelia grown in presence of farnesol is greatly diminished. Furthermore, whereas inhibiting adenylyl cyclase led to a farnesol-like effect, the addition of external cAMP inhibited conidiation without causing a "fluffy" phenotype". This suggests that the mechanisms regulating conidiation in A. niger and A. nidulans are different.
- Issue Date
- 2008
- Status
- published
- Publisher
- Wiley-v C H Verlag Gmbh
- Journal
- Journal of Basic Microbiology
- ISSN
- 0233-111X