Intraneuronal beta-amyloid is a major risk factor - Novel evidence from the APP/PS1KI mouse model
2008 | conference paper. A publication with affiliation to the University of Göttingen.
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Intraneuronal beta-amyloid is a major risk factor - Novel evidence from the APP/PS1KI mouse model
Bayer, T. A.; Breyhan, H.; Duan, K.; Rettig, J. & Wirths, O. (2008)
Neurodegenerative Diseases, 5(3-4) pp. 140-142. 8th International Conference on Alzheimers and Parkinsons Diseases, Salzburg, AUSTRIA.
Basel: Karger. DOI: https://doi.org/10.1159/000113684
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Details
- Authors
- Bayer, Thomas A.; Breyhan, Henning; Duan, Kailai; Rettig, Jens; Wirths, Oliver
- Abstract
- Accumulating evidence points to an important role of intraneuronal P-amyloid (AP) in the development of Alzheimer's disease (AD), with its typical clinical symptoms like memory impairment and changes in personality. We have previously reported on the A beta precursor protein and presenilin-1 knock-out (APP/PS1KI) mouse model with abundant intraneuronal A beta(42) accumulation and a 50% loss of CA1 neurons at 10 months of age. In addition, we observed reduced short- and long-term synaptic plasticity, hippocampal neuron loss, and reduced performance in a working Memory task. These observations support a pivotal role of intraneuronal AP accumulation as a principal pathological trigger in AD. Copyright (c) 2008 S. Karger AG, Basel.
- Issue Date
- 2008
- Status
- published
- Publisher
- Karger
- Journal
- Neurodegenerative Diseases
- Conference
- 8th International Conference on Alzheimers and Parkinsons Diseases
- Conference Place
- Salzburg, AUSTRIA
- ISSN
- 1660-2854
