Notch Signaling: Linking Delta Endocytosis and Cell Polarity

2009 | journal article???letter_note???. A publication with affiliation to the University of Göttingen.

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​Notch Signaling: Linking Delta Endocytosis and Cell Polarity​
Krahn, M. P. & Wodarz, A.​ (2009) 
Developmental Cell, 17(2) pp. 153​-154​.​ DOI: https://doi.org/10.1016/j.devcel.2009.07.018 

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Authors
Krahn, Michael P.; Wodarz, Andreas
Abstract
Activation of Notch by its transmembrane ligand Delta requires the E3 ubiquitin ligases Neuralized or Mind bomb and endocytosis of the ubiquitinated ligand. In this issue of Developmental Cell, Ossipova et al. show that the polarity regulator PAR-1 phosphorylates Mind bomb, leading to the degradation of Mind bomb and to changes in cell fate due to loss of Notch signaling.
Issue Date
2009
Status
published
Publisher
Cell Press
Journal
Developmental Cell 
ISSN
1534-5807

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