Interplay between Platelet Endothelial Cell Adhesion Molecule-1 and Pigment Epithelium-Derived Factor in Non-Small-Cell-Lung Cancer
2016 | journal article. A publication with affiliation to the University of Göttingen.
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Interplay between Platelet Endothelial Cell Adhesion Molecule-1 and Pigment Epithelium-Derived Factor in Non-Small-Cell-Lung Cancer
Emmert, A.; Oellerich, A.; Füzesi, L.; Beushausen, R. W. Beushausen, Regina Waldmann-; Schöndube, F. A.; Bohnenberger, H. & Danner, B. C. (2016)
Open Journal of Thoracic Surgery, 06(04) pp. 47-56. DOI: https://doi.org/10.4236/ojts.2016.64007
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Details
- Authors
- Emmert, Alexander; Oellerich, Angelika; Füzesi, Laszlo; Beushausen, Regina Waldmann-; Schöndube, Friedrich A.; Bohnenberger, Hanibal; Danner, Bernhard C.
- Abstract
- Pigment epithelium-derived factor (PEDF), a potent antiangiogenesis agent, is a multifunctional protein with important roles in regulation of inflammation and angiogenesis. It has recently attracted attention for targeting tumor cells in several types of tumors. PECAM-1 is an integral membrane protein, a cell adhesion molecule with proangiogenic activity and plays an important role in the process of angiogenesis. The correlation between proangiogenic activity PECAM-1 and antiangiogenic activity PEDF in Non-Small-Cell-Lung Cancer has not been reported. The present study was designed to evaluate using immunohistochemical techniques and multivariate analysis the interplay between PECAM-1 and PEDF in NSCLC, especially in adenocarcinoma and in squamous cell carcinoma stage IA-IIIB. Analyzing the mixed study collectively (n = 69), there was no significant correlation (p = 0.553) between PECAM-1 signal and PEDF area. Only including patients with adenocarcinoma (Figure 2), we found a positive correlation between PECAM-1 signal and PEDF area (p = 0.025). In patients with squamous cell carcinoma, we did not find a significant correlation between PECAM-1 signal and PEDF area (p = 0.530). In patients with squamous cell carcinoma, PECAM-1 and PEDF show a significant different expression pattern, measured via staining intensity (p = 0.013). These results might support the hypothesis that squamous cell carcinomas heavily rely on angiogenic processes.
- Issue Date
- 2016
- Journal
- Open Journal of Thoracic Surgery
- ISSN
- 2164-3067
- Language
- English