The Serotonin Receptor Subtype 5b Specifically Interacts with Serotonin Receptor Subtype 1A.
2017 | journal article. A publication with affiliation to the University of Göttingen.
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The Serotonin Receptor Subtype 5b Specifically Interacts with Serotonin Receptor Subtype 1A.
Niebert, S.; van Belle, G. J.; Vogelgesang, S.; Manzke, T. & Niebert, M. (2017)
Frontiers in molecular neuroscience, 10 art. 299. DOI: https://doi.org/10.3389/fnmol.2017.00299
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- Authors
- Niebert, Sabine; van Belle, Gijsbert J.; Vogelgesang, Steffen; Manzke, Till; Niebert, Marcus
- Abstract
- Previously, we described the dysregulation of serotonin (5-HT) receptor subtype 5b (5-ht5b) in a mouse model of Rett syndrome (RTT). 5-ht5b has not been extensively studied, so we set out to characterize it in more detail. Unlike common cell surface receptors, 5-ht5b displays no membrane expression, while receptor clusters are located in endosomes. This unusual subcellular localization is at least in part controlled by glycosylation of the N-terminus, with 5-ht5b possessing fewer glycosylation sites than related receptors. We analyzed whether the localization to endosomes has any functional relevance and found that 5-ht5b receptors can specifically interact with 5-HT1A receptors and retain them in endosomal compartments. This interaction reduces 5-HT1A surface expression and is mediated by interactions between the fourth and fifth trans-membrane domain (TMD). This possibly represents a mechanism by which 5-ht5b receptors regulate the activity of other 5-HT receptor.
- Issue Date
- 2017
- Journal
- Frontiers in molecular neuroscience
- ISSN
- 1662-5099
- Language
- English