Mechanical stimulation in the engineering of heart muscle
2016 | journal article; overview. A publication with affiliation to the University of Göttingen.
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- Authors
- Liaw, Norman Yu ; Zimmermann, Wolfram-Hubertus
- Abstract
- Recreating the beating heart in the laboratory continues to be a formidable bioengineering challenge. The fundamental feature of the heart is its pumping action, requiring considerable mechanical forces to compress a blood filled chamber with a defined in- and outlet Ventricular output crucially depends on venous loading of the ventricles (preload) and on the force generated by the preloaded ventricles to overcome arterial blood pressure (afterload). The rate of contraction is controlled by the spontaneously active sinus node and transmission of its electrical impulses into the ventricles. The underlying principles for these physiological processes are described by the Frank-Starling mechanism and Bowditch phenomenon. It is essential to consider these principles in the design and evaluation of tissue engineered myocardium. This review focuses on current strategies to evoke mechanical loading in hydrogel-based heart muscle engineering. (C) 2015 Published by Elsevier B.V.
- Issue Date
- 2016
- Journal
- Advanced Drug Delivery Reviews
- Project
- SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz
SFB 1002 | C04: Fibroblasten-Kardiomyozyten Interaktion im gesunden und erkrankten Herzen: Mechanismen und therapeutische Interventionen bei Kardiofibroblastopathien - Working Group
- RG Zimmermann (Engineered Human Myocardium)
- ISSN
- 0169-409X
- eISSN
- 1872-8294