Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase
2016 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase
Levchenko, M.; Wuttke, J.-M.; Römpler, K.; Schmidt, B. ; Neifer, K.; Juris, L. & Wissel, M. et al. (2016)
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1863(7) pp. 1624-1632. DOI: https://doi.org/10.1016/j.bbamcr.2016.04.007
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- Authors
- Levchenko, Maria; Wuttke, Jan-Moritz; Römpler, Katharina; Schmidt, Bernhard ; Neifer, Klaus; Juris, Lisa ; Wissel, Mirjam ; Rehling, Peter ; Deckers, Markus
- Abstract
- The cytochrome c oxidase (COX) is the terminal enzyme of the respiratory chain. The complex accepts electrons from cytochrome c and passes them onto molecular oxygen. This process contributes to energy capture in the form of a membrane potential across the inner membrane. The enzyme complex assembles in a stepwise process from the three mitochondria-encoded core subunits Coxl, Cox2 and Cox3, which associate with nuclear-encoded subunits and cofactors. In the yeast Saccharomyces cerevisiae, the cytochrome c oxidase associates with the bc(1)-complex into supercomplexes, allowing efficient energy transduction. Here we report on Cox26 as a protein found in respiratory chain supercomplexes containing cytochrome c oxidase. Our analyses reveal Cox26 as a novel stoichiometric structural subunit of the cytochrome c oxidase. A loss of Cox26 affects cytochrome c oxidase activity and respirasome organization. (C) 2016 Elsevier B.V. All rights reserved.
- Issue Date
- 2016
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- ISSN
- 0167-4889
- eISSN
- 0006-3002
- Language
- English