Expression Patterns of Killer Cell Immunoglobulin-Like Receptors (KIR) of NK-Cell and T-Cell Subsets in Old World Monkeys
2013-05-22 | journal article. A publication with affiliation to the University of Göttingen.
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Expression Patterns of Killer Cell Immunoglobulin-Like Receptors (KIR) of NK-Cell and T-Cell Subsets in Old World Monkeys
Hermes, M.; Albrecht, C.; Schrod, A.; Brameier, M. & Walter, L. (2013)
PLoS ONE, 8(5) art. e64936. DOI: https://doi.org/10.1371/journal.pone.0064936
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- Authors
- Hermes, Meike; Albrecht, Christina; Schrod, Annette; Brameier, Markus; Walter, Lutz
- Abstract
- The expression of killer cell immunoglobulin-like receptors (KIR) on lymphocytes of rhesus macaques and other Old World monkeys was unknown so far. We used our recently established monoclonal anti-rhesus macaque KIR antibodies in multicolour flow cytometry for phenotypic characterization of KIR protein expression on natural killer (NK) cells and T cell subsets of rhesus macaques, cynomolgus macaques, hamadryas baboons, and African green monkeys. Similar to human KIR, we found clonal expression patterns of KIR on NK and T cell subsets in rhesus macaques and differences between individuals using pan-KIR3D antibody 1C7 and antibodies specific for single KIR. Similar results were obtained with lymphocytes from the other studied species. Notably, African green monkeys show only a low frequency of KIR3D expressed on CD8+ abT cells. Contrasting human NK cells are KIR-positive CD56bright NK cells and frequencies of KIR-expressing NK cells that are independent of the presence of their cognate MHC class I ligands in rhesus macaques. Interestingly, the frequency of KIR-expressing cells and the expression strength of KIR3D are correlated in cd T cells of rhesus macaques and CD8+ abT cells of baboons.
- Issue Date
- 22-May-2013
- Journal
- PLoS ONE
- ISSN
- 1932-6203
- Extent
- 10
- Language
- English