Ruthenium(II)biscarboxylate‐Catalyzed Hydrogen‐Isotope Exchange by Alkene C−H Activation
2018 | journal article. A publication with affiliation to the University of Göttingen.
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Details
- Authors
- Bechtoldt, Alexander ; Ackermann, Lutz
- Abstract
- Ruthenium(II) biscarboxylate catalysis enabled efficient hydrogen isotope exchange of acrylic C−H bonds with user‐friendly D2O. The C−H labelling was characterized by excellent positional selectivity and a broad functional group tolerance. The deuteration was successfully conducted on 55 mmol scale with TONs of >1000, while mechanistic studies provided insights into ruthenium(II) oxidase catalysis. The obtained deuterated alkenes enabled the synthesis of labeled standards for mass spectrometry of irradiated foodstuffs.
- Issue Date
- 2018
- Journal
- ChemCatChem
- Organization
- Institut für Organische und Biomolekulare Chemie
- ISSN
- 1867-3880; 1867-3899
- Language
- English