Dickkopf-3 in aberrant endothelial secretome triggers renal fibroblast activation and endothelial-mesenchymal transition
2019 | journal article. A publication with affiliation to the University of Göttingen.
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Dickkopf-3 in aberrant endothelial secretome triggers renal fibroblast activation and endothelial-mesenchymal transition
Lipphardt, M. ; Dihazi, H. ; Jeon, N. L.; Dadafarin, S.; Ratliff, B. B.; Rowe, D. W. & Müller, G. A. et al. (2019)
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 34(1) pp. 49-62. DOI: https://doi.org/10.1093/ndt/gfy100
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Details
- Authors
- Lipphardt, Mark ; Dihazi, Hassan ; Jeon, Noo Li; Dadafarin, Sina; Ratliff, Brian B.; Rowe, David W.; Müller, Gerhard A. ; Goligorsky, Michael S.
- Abstract
- Our laboratory has previously demonstrated that Sirt1endo-/- mice show endothelial dysfunction and exaggerated renal fibrosis, whereas mice with silenced endothelial transforming growth factor beta (TGF-β) signaling are resistant to fibrogenic signals. Considering the fact that the only difference between these mutant mice is confined to the vascular endothelium, this indicates that secreted substances contribute to these contrasting responses.
- Issue Date
- 2019
- Journal
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
- ISSN
- 0931-0509; 1460-2385
- eISSN
- 1460-2385
- Language
- English
