Early NT-proBNP and MR-proANP associated with QoL 1 year after acutely decompensated heart failure: secondary analysis from the MOLITOR trial
2019-12 | journal article. A publication with affiliation to the University of Göttingen.
Jump to: Cite & Linked | Documents & Media | Details | Version history
Cite this publication
Early NT-proBNP and MR-proANP associated with QoL 1 year after acutely decompensated heart failure: secondary analysis from the MOLITOR trial
Zelenak, C.; Chavanon, M.-L. ; Tahirovic, E.; Trippel, T. D.; Tscholl, V.; Stroux, A. & Veskovic, J. et al. (2019)
Biomarkers in Medicine, 13(17) pp. 1493-1507. DOI: https://doi.org/10.2217/bmm-2019-0083
Documents & Media
Details
- Authors
- Zelenak, Christine; Chavanon, Mira-Lynn ; Tahirovic, Elvis; Trippel, Tobias Daniel; Tscholl, Verena; Stroux, Andrea; Veskovic, Jovan; Apostolovic, Svetlana; Obradovic, Danilo; Zdravkovic, Marija; Loncar, Goran; Störk, Stefan; Herrmann-Lingen, Christoph ; Düngen, Hans-Dirk
- Abstract
- Aim: Heart failure negatively impacts quality of life (QoL), which in turn contributes to an adverse long-term prognosis. We aimed at identifying biomarker trajectories after an episode of acutely decompensated heart failure (ADHF) that differ between patients showing average versus impaired QoL 1 year later, thus allowing to predict impaired QoL. Methods: Biomarkers were repeatedly measured throughout the year in 104 ADHF patients. QoL was assessed at discharge and 1 year after ADHF. Logistic regression and receiver operating characteristic analyses were used to identify predictors of impaired QoL while controlling psychosocial confounders. Results: MR-proANP predicted impaired physical and mental QoL. NT-proBNP measurements were important predictors for poor physical QoL. Conclusion: MR-proANP and NT-proBNP predict poor QoL after an epidode of ADHF. The trial is registered at http://clinicaltrials.gov as MOLITOR (IMpact of therapy optimisation On the Level of biomarkers in paTients with Acute and Decompensated ChrOnic HeaRt Failure) with unique identifier: NCT01501981.
- Issue Date
- December-2019
- Journal
- Biomarkers in Medicine
- ISSN
- 1752-0363; 1752-0371
- eISSN
- 1752-0371
- Language
- English