Facile fabrication of pH-responsive nanoparticles from cellulose derivatives via Schiff base formation for controlled release
2019 | journal article. A publication with affiliation to the University of Göttingen.
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Facile fabrication of pH-responsive nanoparticles from cellulose derivatives via Schiff base formation for controlled release
Peng, X.; Liu, P.; Pang, B.; Yao, Y.; Wang, J. & Zhang, K. (2019)
Carbohydrate Polymers, 216 pp. 113-118. DOI: https://doi.org/10.1016/j.carbpol.2019.04.029
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Details
- Authors
- Peng, Xinwen; Liu, Peiwen; Pang, Bo; Yao, Yawen; Wang, Jiaxiu; Zhang, Kai
- Abstract
- A controllable drug delivery system demonstrates a promising tool for diverse biomedical applications. In this work, a group of amphiphilic macromolecules was designed and prepared via Schiff base reactions between 2,3-dialdehyde cellulose (DAC) with oleylamine and amino-containing compounds. Benefiting from the self-assemble process of these amphiphilic macromolecules in the poor solvent, a group of novel pH-responsive nanoparticles (NPs) were facilely fabricated by using nanoprecipitation dropping technique. The high amount of aldehyde groups on DAC chains enabled immobilization of tunable amounts of amine compounds (up to 1.67 mmol/g) in the NPs. Furthermore, the Schiff base bonds in NPs allowed the efficient release of the drug in acidic tumor microenvironment by cleaving the Schiff base linkages. This study demonstrates the formation of a group of novel pH-sensitive and drug-loadable NPs, which provide a simple and efficient drug delivery system for the potential application for cancer treatment.
- Issue Date
- 2019
- Journal
- Carbohydrate Polymers
- Organization
- Fakultät für Forstwissenschaften und Waldökologie ; Burckhardt-Institut ; Abteilung Holztechnologie und Holzwerkstoffe ; Juniorprofessur Holztechnologie und Holzchemie
- eISSN
- 1879-1344
- Language
- English