GOPHER: Generator Of Probes for capture Hi-C Experiments at high Resolution
2019-01-14 | journal article
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Details
- Authors
- Hansen, Peter; Ali, Salaheddine; Blau, Hannah; Danis, Daniel; Hecht, Jochen; Kornak, Uwe ; Lupiáñez, Darío G; Mundlos, Stefan; Steinhaus, Robin; Robinson, Peter N
- Abstract
- Target enrichment combined with chromosome conformation capturing methodologies such as capture Hi-C (CHC) can be used to investigate spatial layouts of genomic regions with high resolution and at scalable costs. A common application of CHC is the investigation of regulatory elements that are in contact with promoters, but CHC can be used for a range of other applications. Therefore, probe design for CHC needs to be adapted to experimental needs, but no flexible tool is currently available for this purpose.
- Issue Date
- 14-January-2019
- Journal
- BMC Genomics
- ISSN
- 1471-2164
- Language
- English